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Rare complication of interferon alpha therapy : retinal vein thrombosis

Journal Volume 68 - 2005
Issue Fasc.3 - Letters
Author(s) Filiz Akyuz, Umit Akyuz, Orhan Kocaman, Sabahattin Kaymakoglu
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(1) Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Gastroenterohepatology Division ; (2) Haydarpaia Numune Educational and Research Hospital, Department of Internal Medicine ; (3) Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine.

Interferon (IFN)-alpha therapy is associated with an increased risk of diabetes mellitus and hypertriglyceri- daemia and can be an additional risk factor for a hyper- coagulable state (1). Diabetes mellitus is well re- cognized side effect of interferon therapy (2), but throm- bosis was reported in some patients with hematological malignancies (3) and a few chronic hepatitis C patients (4-6) whom treated with interferon alpha. There is no reported case about retinal vein thrombosis in chronic hepatitis B patient treated with interferon alpha. We pre- sented an interesting and rare complication of IFN-alpha treatment in this paper.

© Acta Gastro-Enterologica Belgica.